Prima-Temp is leveraging advanced chronobiology and circadian science into a platform of better health outcomes for women.



Prima-Temp leverages the most powerful circadian biomarker – continuous core body temperature (CCBT) to create clinical informatics tools. CCBT is a gold standard for any circadian application and a predictor for multiple biophysical phenomena. A rich scientific literature demonstrates that CCBT is influenced by many hormonal systems, by meals, and by sleep. As a result, CCBT is an information-rich signal with a wide range of health applications.

By capturing all the temp variances across each day, CCBT provides precise information uncapturable by a single measure.


Core body temperature is directly shaped by changes in hormones across the day. Using continuous core body temperature is almost like getting a blood draw every five minutes. It’s a wealth of information about human physiological and hormonal dynamics. Having health-trained AI to find subtle patterns beyond anything possible today is very exciting.
— Prof. Benjamin Smarr, BioE and HDSI, UC San Diego



Prima-Temp is developing solutions that utilize the science of continuous core body temperature to find patterns that predict, confirm and provide information to improve people’s lives beginning with a suite of services for fertility (proceptive & contraceptive) and menopause.

Learn more



Prima-Temp is Accelerating and Converging  Technologies to Create New Clinical Solutions With Chronobiology


Harvesting Big Data into a Mobile Platform:Because Access Matters


Continuous Data:Because Patterns are Predictive


Chronobiology:Because ’When’ Matters




Obesity and Weight Loss

The calories burned during any activity vary from individual to individual and depend on the metabolic rate. A small rise in core temperature can substantially alter metabolic rate. Core body temperature provides personalized, real-time data for more effective weight loss. 

Heat Exhaustion 

An estimated 5 to 10 million people in the United States work in industries where heat stress is a potential health and safety hazard, including firefighters and military personnel. Each year, more than 1,000 people die from heat stroke in the United States. Continuous core temperature monitoring can better detect heat exhaustion and provide early alerts to take action, well before heat exhaustion progresses to heat stroke. 

Sleep Disorders

Recent studies suggest that poor sleep can affect metabolism and weight gain and contribute to mental health conditions such as depression. In addition, the studies infer that poor sleep can impact memory, cognition, day to day performance, and even increase the risk of cancer. A study from Harvard Medical School estimates the costs of undiagnosed sleep apnea to be $65 billion to $165 billion a year, taking into account medical costs, lost productivity, and traffic accidents. Continuous core temperature monitoring provides a much-improved picture of sleep via circadian rhythm, when compared with other sleep tracking systems.

Early Disease Detection

Cancer Chemotherapy Treatment

The disruption of the temperature circadian rhythm has been associated with cancer progression, while its amplification results in cancer inhibition in experimental tumor models. Circadian timing of anti-cancer medications improves treatment tolerability up to fivefold and doubles efficacy.

Sepsis kills an estimated 200,000 Americans every year – more than most cancers, strokes and heart attacks. Sepsis is the most expensive cause of hospitalization in the United States, with an annual cost of more than $24 billion, according to the U.S. Agency for Healthcare Research and Quality. For every hour delay in treatment of sepsis, there is a 7.6% increase in mortality. Continuous temperature monitoring provides critical data that can predict hospital-acquired sepsis in patients several hours before a diagnosis.


A smarter, more informed patient journey can lead to a better care experience and more meaningful relationships with providers.”
— Healthgrades Special Report


Let's Get Social!